Dosagiome

Dosagiome

Definition

The Dosagiome is the complete, dynamic ensemble of dose-response states of all biological regulators — molecules, signals, and conditions — operating within a living system at a given point in time and across its lifespan. It represents the totality of quantitative concentration-effect relationships that govern cellular, tissue, and organismal function, encompassing every endogenous molecule (hormones, metabolites, transcription factors, signaling ligands, reactive species, epigenetic modifiers) and exogenous agent (nutrients, drugs, toxins, nutraceuticals) whose biological effect is a function of its dosage. The Dosagiome is not a static inventory but a continuously shifting, context-dependent regulatory surface whose architecture is shaped by genetics, environment, age, circadian rhythmicity, and disease state.

Core Concept

Where the genome encodes the informational blueprint of life and the proteome captures its functional protein complement, the Dosagiome captures the quantitative regulatory state of life — the full spectrum of concentration-dependent molecular effects that collectively determine whether a cell survives, proliferates, differentiates, senesces, or dies. Every point on the Dosagiome corresponds to a specific biological molecule at a specific concentration producing a specific, measurable effect within a defined biological context. The Dosagiome thus constitutes the quantitative regulatory layer that integrates and modulates all other omes.

Scope

The Dosagiome encompasses:

• The endogenous Dosagiome: all concentration-effect relationships of internally produced biological regulators, including hormones, cytokines, neurotransmitters, metabolites, reactive oxygen and nitrogen species, and epigenetic effectors, across all tissues and cell types.
• The exogenous Dosagiome: dose-response relationships of all externally introduced agents — pharmacological compounds, nutraceuticals, dietary components, environmental toxins, and microbial metabolites — and their systemic effects across omics layers.
• The temporal Dosagiome: the dynamic, time-resolved dimension of the Dosagiome, capturing how concentration-effect relationships shift with circadian rhythm, developmental stage, disease progression, and biological aging.
• The aging Dosagiome: the age-associated reconfiguration of the Dosagiome, reflecting systematic changes in the concentration, sensitivity, and regulatory thresholds of key longevity-associated molecules such as NAD⁺, IGF-1, mTOR, AMPK, sirtuins, SASP components, and steroid hormones — whose progressive dysregulation defines the biochemical landscape of aging.
• The pharmacological Dosagiome: the complete dose-response map of therapeutic and longevity-promoting interventions at multi-omics resolution, providing the empirical foundation for precision dosing in medicine and geroscience.
• The hormetic Dosagiome: the subset of the Dosagiome consisting exclusively of biphasic dose-response relationships, constituting the object of study of Hormesiomics.

The Dosagiome is characterized by the following fundamental properties:

1. Universality — every biological molecule possesses a dose-response profile; no regulator operates independently of its concentration.
2. Context-dependence — the same dose-response relationship may differ across cell types, tissues, developmental stages, genetic backgrounds, and disease states.
3. Dynamism — the Dosagiome is continuously reconfigured by age, environment, circadian state, and pathophysiology.
4. Hierarchical integration — the Dosagiome integrates information from and imposes constraints upon all other omes, including the transcriptome, proteome, metabolome, and epigenome.
5. Threshold non-linearity — the Dosagiome is characterized by critical concentration boundaries, switch points, and bifurcation zones at which qualitatively distinct biological outcomes emerge from quantitative changes in molecular levels.

The Dosagiome provides the conceptual and empirical framework necessary to understand why identical molecules produce radically different — and often opposite — biological outcomes depending on their concentration. It resolves longstanding paradoxes in pharmacology, nutritional science, toxicology, and aging biology by situating all molecular effects within a unified, quantitative dose-space. In geroscience specifically, characterizing the aging Dosagiome — the systematic drift of molecular concentrations and regulatory sensitivities that accompanies biological aging — may reveal the precise quantitative interventions required to restore a youthful dosage landscape and achieve Gerostasis. Mapping the Dosagiome at individual resolution constitutes a foundational goal of precision medicine and longevity science.

Relationship to Dosagiomics and Hormesiomics

The Dosagiome is the object of study of Dosagiomics, which provides the experimental, computational, and systems-biological methodologies for its characterization. The Hormetic Dosagiome — the biphasic subset of the Dosagiome — is the specific object of study of Hormesiomics. Together, these three terms constitute a unified conceptual framework: the Dosagiome (the object), Dosagiomics (the discipline), and Hormesiomics (the biphasic subdiscipline).

Coined by

Jong Bhak, KOGIC / AgingLab, UNIST, Republic of Korea (2025)

See also

Dosagiomics · Hormesiomics · Hormesis · GeroIndex · Gerostasis · Omics · Pharmacodynamics · Aging Hallmarks · Systems Biology · Precision Medicine · Metabolome · Proteome · Epigenome

The three terms now form a coherent, citable trilogy on Qeios: