Hormesiomics
Definition
Hormesiomics is the systematic, large-scale omics-based investigation of hormetic phenomena in biological systems. It encompasses the comprehensive mapping and analysis of genomic, transcriptomic, proteomic, metabolomic, and epigenomic responses to hormetic stimuli — agents or conditions that elicit adaptive, beneficial effects at low doses and inhibitory or toxic effects at high doses. The field aims to characterize the full molecular architecture of biphasic dose-response landscapes across cell types, tissues, and organisms, with the goal of identifying universal and context-specific hormetic regulators, network topologies, and biological thresholds.
Scope
Hormesiomics integrates data from multiple omics layers to resolve how organisms sense, transduce, and adapt to sub-threshold stressors — including caloric restriction, exercise-induced oxidative stress, low-dose radiation, xenobiotics, heat shock, and pharmacological senolytics. It applies computational and systems biology approaches to construct hormetic interactomes, identify hormesis-associated biomarkers, and model the dose-response dynamics of adaptive regulatory networks at molecular resolution.
Significance
As a subfield at the intersection of toxicology, systems biology, and geroscience, hormesiomics provides a quantitative framework for understanding the mechanistic basis of adaptive resilience, stress-response hormones, and longevity-associated pathways. It is particularly relevant to aging research, where hormetic interventions are hypothesized to delay or reverse hallmarks of aging through the activation of conserved stress-response programs such as autophagy, mitophagy, heat shock response, NRF2-mediated antioxidant signaling, and AMPK/mTOR pathway modulation.
Coined by
Jong Bhak, KOGIC/AgingLab, UNIST, Republic of Korea (2025)
See also
Hormesis · Geroscience · Geroindex · Omics · Toxicogenomics · Adaptive Stress Response · Senescence · Longevity Biology
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