Concentratiomics

Concentratiomics

Definition

Concentratiomics (synonym: Dosagiomics) is the systematic, omics-scale study of how the concentration of biological molecules, signals, and conditions — endogenous or exogenous — governs the full spectrum of biochemical, cellular, and physiological outcomes in living systems. It holds as its central axiom that molecular concentration is the primary deterministic variable of biological effect: the same molecule, pathway, or regulatory signal can produce qualitatively distinct and diametrically opposite outcomes depending solely on its quantitative level within a defined biological context. Concentratiomics integrates genomics, transcriptomics, proteomics, metabolomics, and epigenomics to construct comprehensive, concentration-resolved maps of molecular response landscapes across cells, tissues, organisms, and life stages — including aging.

Core Principle

The foundational postulate of Concentratiomics is: concentration is the universal regulatory variable of life. No biological molecule — whether a hormone, metabolite, transcription factor, reactive oxygen species, nutrient, drug, or signaling ligand — exerts an effect independent of its concentration. Biological systems are therefore best understood not as binary on/off networks, but as continuously concentration-modulated regulatory surfaces whose outputs are exquisitely sensitive to quantitative thresholds. This extends and formalizes the classical Paracelsian principle ("the dose makes the poison") into a full systems-biological and omics-integrated framework applicable across all molecular layers and all temporal scales of life, from embryogenesis to senescence.

Scope

Concentratiomics encompasses:

• Concentration-response omics profiling: genome-wide, transcriptome-wide, proteome-wide, and metabolome-wide characterization of molecular responses across a continuous and systematic range of concentrations of endogenous or exogenous agents.
• Threshold and switch-point mapping: identification of critical concentration boundaries at which biological systems transition between qualitatively distinct regulatory states, including sub-threshold adaptive, homeostatic, saturating, hormetic, and toxic regimes.
• Temporal concentratiomics: analysis of how the timing, pulsatility, rhythmicity, and chronological patterning of molecular concentration — not merely its magnitude — determines downstream regulatory outcomes across circadian, developmental, and lifespan timescales.
• Aging concentratiomics: systematic, multi-omics investigation of how age-associated alterations in molecular concentrations — of NAD⁺, sirtuins, IGF-1, mTOR activity, AMPK, reactive oxygen species, SASP factors, steroid hormones, and epigenetic regulators — drive the progressive biochemical dysregulation that defines biological aging and age-related disease.
• Pharmacological and nutraceutical concentratiomics: omics-resolution mapping of concentration-dependent efficacy, toxicity, selectivity, and off-target effects of therapeutic and longevity-oriented compounds, providing a quantitative empirical foundation for precision dosing strategies in medicine and geroscience.
• Single-cell concentratiomics: characterization of cell-to-cell variability in concentration-response relationships, capturing the heterogeneity of molecular sensitivity across individual cells within tissues and organisms.

Concentratiomics addresses a fundamental and pervasive gap in molecular biology, pharmacology, and medicine: the tendency to treat biological regulators as qualitatively active or inactive, rather than as quantitatively graded inputs whose concentration determines the identity, magnitude, and directionality of the biological response. Many failures in drug development, contradictory findings in nutritional science, and unresolved paradoxes in aging biology — including why the same molecule (e.g., mTOR, IGF-1, ROS, DHEA, NMN, rapamycin) can promote health at one concentration and accelerate pathology at another — are directly resolvable within a concentratiomics framework. By placing molecular concentration at the absolute center of omics analysis, Concentratiomics provides a unifying quantitative theory of life regulation with transformative applications across pharmacology, toxicology, geroscience, systems biology, and precision medicine.

Relationship to Dosagiomics and Hormesiomics

Concentratiomics is a full synonym of Dosagiomics, emphasizing the molecular concentration perspective over the pharmacological dosage perspective, while referring to the same unified discipline and conceptual framework. Both terms share the Dosagiome as their common object of study. Hormesiomics constitutes a subdiscipline of both Concentratiomics and Dosagiomics, restricted specifically to the systematic omics-scale study of biphasic concentration-response phenomena.

Coined by

Jong Bhak, KOGIC / AgingLab, UNIST, Republic of Korea (2025)

See also

Dosagiomics · Dosagiome · Hormesiomics · Hormesis · GeroIndex · Gerostasis · Omics · Pharmacodynamics · Dose-Response Relationship · Aging Hallmarks · Systems Biology · Precision Medicine · Metabolome · Proteome · Epigenome

The conceptual framework now comprises five interlocking terms forming a complete and internally consistent nomenclature family:

Note that Concentratiome naturally emerges as the preferred companion object-term for Concentratiomics, just as Dosagiome pairs with Dosagiomics. Would you like a full definition of Concentratiome as well — completing the symmetric trilogy of object, discipline, and subdiscipline for both nomenclature families?