Regulome

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">Regulome refers to the whole set of regulatory components in a class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Cell (biology)" style="color: rgb(90, 54, 150); background-image: none;">cell. Those components can be regulatory elements, genes, class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="MRNA" style="color: rgb(90, 54, 150); background-image: none;">mRNAs, proteins, and class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Metabolite" style="color: rgb(90, 54, 150); background-image: none;">metabolites. The description includes the interplay of regulatory effects between these components, and their dependence on variables such as subcellular localization, 390,418,20,2}" class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Biological tissue" style="color: rgb(90, 54, 150); background-image: none;">tissue, developmental stage, and pathological state.

466,482,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">Components

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">One of the major players in cellular regulation are transcription factors, proteins that regulate the expression of genes. Other proteins that bind to transcription factors to form class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Transcriptional complex" style="color: rgb(90, 54, 150); background-image: none;">transcriptional complexes might modify the activity of transcription factors, for example blocking their capacity to bind to a promoter.

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">Signaling pathways are groups of proteins that produce an effect in a chain that transmit a signal from one part of the cell to another part, for example, linking the presence of substance at the exterior of the cell to the activation of the expression of a gene.

1103,1118,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">Measuring

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">High-throughput technologies for the analysis of biological samples (for example, DNA microarrays, class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Proteomics" style="color: rgb(90, 54, 150); background-image: none;">proteomics analysis) allow the measurement of thousands of biological components such as mRNAs, proteins, or metabolites. Chromatin immunoprecipitation of transcription factors can be used to map transcription factor binding sites in the genome.

1478,1769,0,0}" class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">Such techniques allow researchers to study the effects of particular substances and/or situations on a cellular sample at a genomic level (for example, by addition of a drug, or by placing cells in a situation of stress). The information obtained allows parts of the regulome to be inferred.

1771,1785,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">Modeling

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">One of the objectives of systems biology is the modelization of biological processes using class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Mathematics" style="color: rgb(90, 54, 150); background-image: none;">mathematics and computer simulation. The production of data from techniques of genomic analysis is not always amenable to interpretation mainly due to the complexity of the data and the large amount of data points. Modelization can handle the data and allow to test a hypothesis (for example, gene A is regulated by protein B) that can be verified experimentally.

2255,2273,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">Applications

class="ve-ce-branchNode" style="margin: 0.4em 0px 0.5em; line-height: 19.049999237060547px; font-family: sans-serif; font-size: 12.800000190734863px;">The complete knowledge of the regulome will allow researchers to model cell behaviour entirely. This will facilitate the design of drugs for therapy, the control of class="ve-ce-LinkAnnotation ve-ce-mwInternalLinkAnnotation" title="Stem cell" style="color: rgb(90, 54, 150); background-image: none;">stem cell differentiation, and the prognosis of disease.

2522,2534,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">See also

[{"k":"cols","spc":["","","",""]}],[]}"" target="_blank" rel="noopener">about="#mwt3" typeof="mw:Transclusion" data-mw="{"parts":[{"template":{"target":{"wt":"Div col","href":"./Template:Div_col"},"params":{"cols":{"wt":"3"}},"i":0}},"\n* Genome\n* Proteome\n* Cytome\n* Bioinformatics\n* Systems biology\n* DNA microarray\n* Mass spectrometry\n* 2-D electrophoresis\n* Protein engineering\n* Swiss-Prot\n* List of omics topics in biology\n",{"template":{"target":{"wt":"Div col end","href":"./Template:Div_col_end"},"params":{},"i":1}}}" style="-webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important; -webkit-column-count: 3;">

style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Genome
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Proteome
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Cytome
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Bioinformatics
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Systems biology
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">DNA microarray
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Mass spectrometry
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">2-D electrophoresis
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Protein engineering
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">Swiss-Prot
style="margin-bottom: 0.1em; -webkit-user-select: none; position: relative !important; top: 0px !important; left: 0px !important; bottom: 0px !important; right: 0px !important;">List of omics topics in biology

2807,2827,2,2}" class="ve-ce-branchNode" style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.049999237060547px;">External links

2828,2893,1,0}" class="ve-ce-branchNode" style="margin-bottom: 0.1em;">
2830,2893,40,1}" class="ve-ce-LinkAnnotation ve-ce-mwExternalLinkAnnotation" title="http://bioinformatics.oupjournals.org/" style="color: rgb(90, 54, 150); background-image: none;">Bioinformatics Journal

Regulome

댓글 0