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The project utilizes a combination of informatics, evolutionary biology, microbiology and eukaryotic genetics to identify pathogen genes which are more similar to host genes than expected, and likely to interact with, or mimic, their host’s gene functions. In addition, potential pathogenicity islands in genomes are being identified. A database of these genes is being built, which will be updated in an automated fashion, based on the increasing number of pathogen genomes being sequenced. Candidate functions identified by our informatics approach will be tested in the laboratory to investigate their role in pathogen infection and host interaction.